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Am J Physiol Cell Physiol. Olfactory receptor 78 participates in carotid body response to a wide range of low O2 levels but not severe hypoxia. Elected Fellow of the American Physiological Society Inaugural C. Mahabalinos Award, Physiological Society of India Julius H. Plenary Lecture. British Physiological Soc. Birmingham, U. Neil S. View in: PubMed. Physiol Genomics. Role of olfactory receptor78 in carotid body-dependent sympathetic activation and hypertension in murine models of chronic intermittent hypoxia.

J Neurophysiol. Gaseous transmitter regulation of hypoxia-evoked catecholamine secretion from murine adrenal chromaffin cells. Olfactory receptor 78 regulates erythropoietin and cardiorespiratory responses to hypobaric hypoxia.

J Appl Physiol Am J Physiol Cell Physiol. Hypoxia-inducible factors and obstructive sleep apnea. J Clin Invest. Olfactory receptor 78 participates in carotid body response to a wide range of low O2 levels but not severe hypoxia.

Prabhakar NR. Physiology Bethesda. Role of the carotid chemoreceptors in insulin-mediated sympathoexcitation in humans. Curr Opin Physiol. Long-term facilitation of catecholamine secretion from adrenal chromaffin cells of neonatal rats by chronic intermittent hypoxia. PLoS One. Recent advances in understanding the physiology of hypoxic sensing by the carotid body. Adv Exp Med Biol. H2S mediates carotid body response to hypoxia but not anoxia.

Respir Physiol Neurobiol. Reactive oxygen radicals and gaseous transmitters in carotid body activation by intermittent hypoxia. Cell Tissue Res. The role of hypoxia-inducible factors in carotid body patho physiology. J Physiol. Nanduri J, Prabhakar NR. Immunohistochemistry of the Carotid Body. Methods Mol Biol. DNA methylation in the central and efferent limbs of the chemoreflex requires carotid body neural activity.

Epigenetic changes by DNA methylation in chronic and intermittent hypoxia. HIF-1a is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium. Systems biology of oxygen homeostasis.

Complementary roles of gasotransmitters CO and H2S in sleep apnea. Integrative genomics reveals hypoxia inducible genes that are associated with a poor prognosis in neuroblastoma patients. H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea.

Sci Signal. Epigenetic regulation of redox state mediates persistent cardiorespiratory abnormalities after long-term intermittent hypoxia. Carotid body chemoreflex: a driver of autonomic abnormalities in sleep apnoea. Exp Physiol. Front Neurosci. Calpain activation by ROS mediates human ether-a-go-go-related gene protein degradation by intermittent hypoxia. Oxygen Sensing and Homeostasis. Regulation of carotid body oxygen sensing by hypoxia-inducible factors. Pflugers Arch.

Neural regulation of hypoxia-inducible factors and redox state drives the pathogenesis of hypertension in a rodent model of sleep apnea.

Protein kinase G-regulated production of H2S governs oxygen sensing. Peripheral chemoreception and arterial pressure responses to intermittent hypoxia. Compr Physiol. Hypoxia-inducible factors and hypertension: lessons from sleep apnea syndrome. J Mol Med Berl. Neuromolecular mechanisms mediating the effects of chronic intermittent hypoxia on adrenal medulla. Regulation of hypoxia-inducible factor-a isoforms and redox state by carotid body neural activity in rats.

The human carotid body releases acetylcholine, ATP and cytokines during hypoxia. TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma. Cell Rep. Is insulin the new intermittent hypoxia?

Med Hypotheses. Inherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema. Prabhakar NR, Peers C. Gasotransmitter regulation of ion channels: a key step in O2 sensing by the carotid body. Biochem J. Xanthine oxidase mediates hypoxia-inducible factor-2a degradation by intermittent hypoxia.

Role of oxidative stress-induced endothelin-converting enzyme activity in the alteration of carotid body function by chronic intermittent hypoxia.

Central and peripheral factors contributing to obstructive sleep apneas. Kumar P, Prabhakar NR. Peripheral chemoreceptors: function and plasticity of the carotid body. Mutual antagonism between hypoxia-inducible factors 1a and 2a regulates oxygen sensing and cardio-respiratory homeostasis. Sensing hypoxia: physiology, genetics and epigenetics.

Differential regulation of tyrosine hydroxylase by continuous and intermittent hypoxia. Hydrogen sulfide H 2 S : a physiologic mediator of carotid body response to hypoxia. The role of hypoxia-inducible factors in oxygen sensing by the carotid body. Most visited doctors. Recently added doctors. Accepts Medicare Assignment. He does accept the payment amount Medicare approves and not to bill you for more than the Medicare deductible and coinsurance. Holy Cross Hospital. Metrosouth Medical Center.

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